17-phenyl trinor Prostaglandin F2a ethyl amide

17-phenyl trinor Prostaglandin F2a ethyl amide (17-phenyl trinor PGF2a ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Investigations in our lab have shown that 17-phenyl trinor PGF2a ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours.{9311} The free acid, 17-phenyl trinor PGF2a, is a potent FP receptor agonist.{2058,1374} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.