Product description
(S)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and a COX-1 and COX-2 inhibitor (IC50s = 2.6 and 1.53 µM, respectively).{1286} It inhibits NF-kB transactivation in a reporter assay using Jurkat T cells (IC50 = 61.7 µM).{6935} (S)-Ibuprofen reduces aggregation in platelet-rich plasma and washed isolated human platelets (IC50s = 88 and 0.6 µM, respectively).{27418} It decreases superoxide formation and B-glucuronidase release induced by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495), as well as leukotriene B4 (LTB4; Item No. 20110) formation induced by calcimycin (A23187; Item No. 11016), in human polymorphonuclear (PMN) cells (IC50s = 0.50, 0.53, and 0.14 µM, respectively). (S)-Ibuprofen increases the latency to withdrawal in hot plate and tail-flick tests in mice (ED50s = 64 and 54 mg/kg, respectively), as well as reduces paw swelling in a mouse model of carrageenan-induced paw edema (ED50 = 57 mg/kg).{65662} Formulations containing (+-)-ibuprofen have been used in the treatment of fever and mild-to-severe pain.
Specifications
CAS number
51146-56-6
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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