15-keto Fluprostenol isopropyl ester

Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.{8839,9613} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.{3586} The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.