(+)-Cloprostenol

(+)-Cloprostenol is a synthetic analog of prostaglandin F2a (PGF2a). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF2a in terminating pregnancy when given subcutaneously at a daily dose of 0.125 ?g/kg in rats and hamsters, without the side effects associated with PGF2a.{1182} (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 pM.{4404}