(+-)-Cloprostenol (sodium salt)

(+-)-Cloprostenol (sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid. Cloprostenol is a synthetic analog of prostaglandin F2a (PGF2a; Item No. 16010). It is 200 times and 100 times more potent than PGF2a in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2a.{1182} The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.{1182} Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10-12 M.{4404}