8-iso-15-keto Prostaglandin F2a

8-iso-15-keto Prostaglandin F2a (8-iso-15-keto PGF2a) is a metabolite of the isoprostane 8-iso PGF2a in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2a) is a prostaglandin-like product of non-specific lipid peroxidation.{320} In both humans and monkeys, exogenously infused 8-iso PGF2a is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by B-oxidation.{6907} A similar pattern is observed when tritiated 8-iso PGF2a is infused into rabbits.{11209} Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2a was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2a. 8-iso -15-keto PGF2a is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.{11221}