8-iso-13,14-dihydro-15-keto Prostaglandin F2a

8-iso-13,14-dihydro-15-keto Prostaglandin F2a (8-iso-13,14-dihydro-15-keto PGF2a) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2a), in rabbits, monkeys and humans.{6907} 8-iso PGF2a is a PG-like product of non-specific lipid peroxidation.{320} In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by B-oxidation.{6907} A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits.{11209} Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2a was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2a weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.{11145}