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6-Thioguanine
15774-1
1 g
€84
Product description
6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.{25757,25758} This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.{25755}
Specifications
CAS number
154-42-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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