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Rat Anti-Mouse CD11b/Mac-1a-APC
1561-11
0,1 mg
€251
Product description
CD11b, the integrin ?M subunit, combines with CD18, the integrin ?2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.
Specifications
Applications
FC
Host
Rat
Clonality
Monoclonal
Clone
M1/70
Isotype
IgG2b
Supplier
Southern Biotech
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
2-8°C
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Rat Anti-Mouse CD11b/Mac-1a-APC
1561-11
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Rat Anti-Mouse CD11b/Mac-1a-APC
1561-11
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