Product description
In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an ? chain (CD8?) and a ? chain (CD8?); and (ii) a homodimer of two ? chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8? without CD8?. It has been suggested that CD8+?- T cells mature extrathymically, while development of the CD8?+?+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8?+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.
Specifications
Applications
FC
Host
Rat
Clonality
Monoclonal
Clone
53-6.7
Isotype
IgG2a
Supplier
Southern Biotech
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
2-8°C

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Rat Anti-Mouse CD8a/Ly-2-APC

1550-11

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Rat Anti-Mouse CD8a/Ly-2-APC

1550-11

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