1,2-Dioleoyl-sn-glycero-3-PE

1,2-Dioleoyl-sn-glycero-3-PE (1,2-DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. The compound features the same diacylglycerol stereochemistry as that of the natural compound. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.{9185,24259,24260}