(-)-Thalidomide

(-)-Thalidomide is an active enantiomer of (+-)-thalidomide (Item No. 14610) and has immunomodulatory and teratogenic activities.{54270,54271,54272} It enhances TNF-a production induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells when used at concentrations ranging from 0.1 to 100 µM.{54270} Preincubation of isolated Rhode Island Red (RIR) chicken donor blood with (-)-thalidomide (10 mg/ml) reduces recipient chicken embryo splenomegaly in a model of graft versus host disease.{54271} (-)-Thalidomide (150 mg/kg) induces fetal malformations when administered to pregnant female rabbits.{54272}