Product description
The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20a-HSD and the other three being 3a-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20a-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 ?M), and AKR1C4 (Ki = 18.2 ?M).{17245} Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).{17245}
Specifications
CAS number
4906-68-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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