Product description
(-)-Sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 18 nM).{26165} It is selective for DPP-4 over DPP-8 (IC50 = 48 µM) as well as several other peptidases, including DPP-9, DPP-2, and amino peptidase P.{26165,26164} (-)-Sitagliptin improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet fed rats as well as ob/ob and high-fat diet fed mice.{26071} It also reduces hyperglycemia in mice fed a high-fat diet with diabetes induced by streptozotocin (Item No. 13104). Formulations containing (-)-sitagliptin have been used in the treatment of type 2 diabetes mellitus.
Specifications
CAS number
654671-78-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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(-)-Sitagliptin (phosphate)

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