Product description
18B-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18B-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18B-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 ?M).{21413} At 100 mg/kg/day, 18B-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats.{21415} 18B-Glycyrrhetinic acid inhibits mammalian DNA polymerases a, y, k, and ? with IC50 values of 16.1, 19.3, 15.8, and 13.7 ?M, respectively.{21414} At 100-200 ?M, 18B-glycyrrhetinic acid suppresses LPS-induced TNF-a production and NF-kB activation in mouse macrophages.{21414}
Specifications
CAS number
471-53-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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18B-Glycyrrhetinic Acid

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