6a-Methylprednisolone 21-hemisuccinate is a prodrug form of the synthetic glucocorticoid methylprednisolone (Item No. 15013).{21229} It is converted to methylprednisolone by carboxylesterase 2 (CES2).{65360} Nanoliposomes containing 6a-methylprednisolone 21-hemisuccinate decreases disease severity in a rat model of adjuvant-induced arthritis.{65361} Formulations containing 6a-methylprednisolone 21-hemisuccinate have been used as anti-inflammatory agents and immunosuppressants with indications in allergic reactions and dermatologic, renal, gastrointestinal, respiratory, and ophthalmic diseases, as well as endocrine, hematologic, and rheumatic disorders.