T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium.{20907} It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1B, TNF-a, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs).{20906} In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg).{20907} It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.
Specifications
Size
5 mg
CAS number
21259-20-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C