(S)-Ketorolac

(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 µM for COX-1 and COX-2, respectively).{20315} (S)-Ketorolac is approximately twice as potent as the racemic mixture (Item No. 9001148) and 60 times more potent than (R)-ketorolac in a rat pain assay.{34230} (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac.{34229} Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.{10631}