Aflatoxin B1 (AFB1) is a genotoxic mycotoxin that has been found in Aspergillus.{52844,20403} It induces the formation of DNA adducts in rat liver microsomes.{52844} AFB1 induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells.{20403} In vivo, AFB1 (50 and 100 ug/kg) induces hepatocellular carcinoma tumor formation in rats.{52845}
Specifications
Size
5 mg
CAS number
1162-65-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C