4'-O-Methylhonokiol

4'-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.{58070,58073,58071,58072} It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml).{58070} 4'-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.{58073} In vivo, 4'-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer's disease induced by amyloid-B 1-42 (AB42) when administered at a dose of 1 mg/kg.{58071} 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.{58072}