Product description
MEK (MAPKK, kinase of mitogen-activated protein kinase) is the medium one of three components of MAP kinase cascade – an important signaling pathway that regulates cell growth and differentiation. Raf (MAPKKK) activates MEK 1 and 2 via phosphorylation of two serine residues (Ser218 and Ser222). Activated MEK 1/2 then acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on ERK (MAPK, mitogen-activated protein kinase). This phosphorylation of ERK by MEK 1/2 is a critical step in the MAP kinase cascade. Phosphorylated ERK is capable of translocating to the nucleus, where it regulates gene expression by activating transcription factors.
Specifications
Applications
WB
Host
Rabbit
Clonality
Polyclonal
Clone
PAb (508)
Isotype
Rabbit polyclonal
Supplier
Exbio
Shipping & storage
Storage temperature
2-8°C

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Productname

Rabbit Polyclonal to MEK 1/2 / MAPKK 1/2, Clone Polyclonal, purified

11-508-C050

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Productname

Rabbit Polyclonal to MEK 1/2 / MAPKK 1/2, Clone Polyclonal, purified

11-508-C050

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


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