Product description
SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
Specifications
Applications
IHC-P, WB
Host
Rabbit
Clonality
Polyclonal
Clone
PAb (412)
Isotype
Rabbit polyclonal
Supplier
Exbio
Shipping & storage
Storage temperature
2-8°C

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Productname

Rabbit Polyclonal to SLP76, Clone Polyclonal, purified

11-412-C100

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Productname

Rabbit Polyclonal to SLP76, Clone Polyclonal, purified

11-412-C100

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


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