Product description
STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.
Specifications
Applications
IP, WB
Host
Mouse
Clonality
Monoclonal
Clone
PSM1
Isotype
Mouse IgG1
Supplier
Exbio
Shipping & storage
Storage temperature
2-8°C

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Productname

Mouse Monoclonal to STAT1 (Phospho-Ser727), Clone PSM1, purified

11-372-C100

By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


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Productname

Mouse Monoclonal to STAT1 (Phospho-Ser727), Clone PSM1, purified

11-372-C100

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


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