Toggle Nav
Anti-PAG1 Purified
11-346-C100
0,1 mg
€231
Product description
PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
Specifications
Applications
IP, IHC-P, WB
Host
Mouse
Clonality
Monoclonal
Clone
PAG-C1
Isotype
Mouse IgG2b
Supplier
Exbio
Product status
RUO
Shipping & storage
Storage temperature
2-8°C
Do you have any questions about this product?
Order your product by email
Productname
Anti-PAG1 Purified
11-346-C100
By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Request a sample
Productname
Anti-PAG1 Purified
11-346-C100
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Are you looking for specific products, alternatives or documentation?
