Clofibrate is a selective agonist of peroxisome proliferator-activated receptor a (PPARa).{10670} In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 uM for murine and human PPARa, respectively. It also binds to PPARy but with 10-fold less affinity and is inactive at PPARD at concentrations up to 100 uM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.
5 g
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Cayman Chemical
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