Product description
1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 1.5 nM versus 1.0 ?M, respectively).{17286} The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 1.5 nM for c-Fyn-as1 versus 0.6 ?M for c-Fyn; 7.0 nM for c-Abl-as2 versus 0.6 ?M for c-Abl; 15 nM for Cdk2-as1 versus 18 ?M for Cdk2).{17287} This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.{17287,20028,20029}
Specifications
CAS number
221243-82-9
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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