Product description
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1?-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
Specifications
Applications
IP, WB, ELISA
Host
Mouse
Clonality
Monoclonal
Clone
1A11
Isotype
IgG1
Supplier
Southern Biotech
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
2-8°C

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Mouse Anti-Human FADD-UNLB

10941-01

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Productname

Mouse Anti-Human FADD-UNLB

10941-01

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