Product description
10-Nitrooleate-d17 is intended for use as an internal standard for the quantification of 10-nitrooleate (Item No. 10008043) by GC- or LC-MS. Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2; Item No. 10037), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARy and can also decompose or be metabolized to release nitric oxide.{11912,13284,13287,13288} 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (Item No. 10008042) (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid (Item No. 90260) in approximately equal proportions in vivo.{14255} Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 +- 52 nM and 302 +- 369 nM, respectively. OA-NO2 activates PPARy approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM.{14255}
Specifications
CAS number
2749984-40-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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