Product description
Eicosapentaenoic acid (EPA; Item No. 90110) is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms.{18671} The major product of this epoxygenase pathway, (+-)17(18)-EpETE (Item No. 50861), relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKa channel subunits.{9825,18669,18670} (+-)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.{18672} The biological actions and physiological effects of this epoxide remain to be determined.
Specifications
CAS number
851378-93-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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