3-amino Benzamide

3-amino benzamide is an inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 5.4 µM in C3H/10T1/2 mouse stem cells).{64682} It inhibits spontaneous, as well as FGF2-induced, invasiveness of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 50 µM.{19999} 3-amino benzamide (50 µM) induces tubulogenesis and reduces FGF2-induced expression of the gene encoding urokinase-type plasminogen activator (uPA) in HUVECs. It reduces telomere length in HeLaS3 human cervical cancer cells and non-cancerous COM3 hamster cells in a concentration-dependent manner.{19998}