Product description
11-Hydroxysteroid dehydrogenase type 2 (11B-HSD2) plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11B-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.{11854} Expression of 11B-HSD2 mRNA and protein has been shown in placenta and mineralocorticoid target tissues, particularly the kidney.{12000} In mouse, expression of this enzyme is tissue- and developmentally specific, indicating the importance of the enzyme in regulating glucocorticoid-mediated maturation.{11999} Cayman’s 11B-HSD2 polyclonal antibody detects a band at around 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.
Specifications
Applications
WB
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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11B-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide

10242-200

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11B-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide

10242-200

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