8-iso Prostaglandin A2

8-iso Prostaglandin A2 (8-iso PGA2) is an isoprostane. It is produced by the non-enzymatic oxidation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{7324,14267} 8-iso PGA2 (100 µM) induces calcium influx in HEK293 cells expressing human transient receptor potential ankyrin 1 (TRPA1) and isolated mouse trigeminal neurons.{21769} It potentiates glutamate-induced cytotoxicity and decreases glutathione (GSH) levels in HT22 hippocampal cells when used at concentrations of 1 and 30 µM, respectively.{16387} 8-iso PGA2 (10 µM) inhibits VEGF-induced migration and tube formation of human coronary artery endothelial cells, an effect that can be reversed by the TP receptor antagonist SQ 29,548 (Item No. 19025).{20091}