24(R)-hydroxy Cholesterol

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis.{15406} 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRa and LXRB nuclear receptors with slightly reduced potency (EC50 = 7 and 4 ?M, respectively) compared to the natural isomer (EC50 = 4 and 3 ?M, respectively).{15406,25539}