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(+-)14(15)-EpETE
10173-500
500 ug
€907
Product description
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.{6485,7204} Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (+-)14(15)-EpETrE (Item No. 50651) which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (+-)14(15)-EpETE is the w-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (+-)14(15)-EpETE has not yet been determined.
Specifications
CAS number
131339-24-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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(+-)14(15)-EpETE
10173-500
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10173-500
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