6(S)-Lipoxin A4

6(S)-Lipoxin A4 (6(S)-LXA4) is an isomer of the trihydroxy fatty acid LXA4 (Item No. 90410). It is formed from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) through double lipoxygenase-catalyzed reactions initiated by either 5-lipoxygenase (5-LO) followed by 12- or 15-LO, with a leukotriene A4 (LTA4) intermediate, or by 15-LO followed by 5-LO, with 15(S)-HETE (Item No. 34720) and 5(S)-Hp-15(S)-HETE intermediates.{35339} The generation of 6(S)-LXA4 and LXA4 typically requires transcellular metabolism of arachidonic acid.{35339,35079} For example, LTA4 synthesized in neutrophils by 5-LO is metabolized to LXA4 in platelets by 12-LO.{35339} 6(S)-LXA4 has been detected in co-incubations of human polymorphonuclear leukocytes (PMNs) and platelets.{68191}