1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol (1-AG; Item No. 62150).{10322} 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM.{43503} It prevents TNF-? and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS.{43504} It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.{43505}
10 mg
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Cayman Chemical
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