1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol (1-AG; Item No. 62150).{10322} 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM.{43503} It prevents TNF-? and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS.{43504} It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.{43505}
Specifications
Size
10 mg
CAS number
799268-65-8
Supplier
Cayman Chemical
Shipping & storage
Storage temperature
-80°C