Diallyl Trisulfide

Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor.{16966} It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 ?M){16967} and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 ?M).{16969} DATS suppresses the growth of PC-3 xenografts in vivo in mice{16968} and induces vascular smooth muscle relaxation.{16966} Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.{16970,16971}