5-Iodotubercidin (Itu) is an adenosine derivative that initiates glycogen synthesis in hepatocytes by causing inactivation of phosphorylase a and activation of glycogen synthase a (maximal effects with ~20 uM Itu).{15220} Itu can inhibit a broad range of PKs including PKA (IC50 = 5-10 uM), phosphorylase kinase (IC50 = 5-10 uM), casein kinase I (IC50 = 0.4 uM) and II (IC50 = 10.9 uM), and PKC (IC50 = 0.4 uM), which appears to account for its glycogenic action.{15083} Itu is also a highly potent inhibitor of ERK2 (Ki = 525 nM), a protein kinase with important roles in cell proliferation.{15221} Mediated by the inhibition of acetyl-CoA carboxylase, Itu increases fatty acid oxidation activity of the liver at the expense of lipogenesis.{15219}
5 mg
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Cayman Chemical
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