Product description
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver.{15406} 24(S)-hydroxy cholesterol potently activates LXRa and LXRB nuclear receptors (EC50 = 4 and 3 ?M, respectively), causing upregulation of cholesterol-lowering genes.{15406,25539,15410} In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.{15406}
Specifications
CAS number
474-73-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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24(S)-hydroxy Cholesterol

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24(S)-hydroxy Cholesterol

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