17(S)-HDHA is a hydroxy fatty acid formed from docosahexaenoic acid (DHA; Item No. 90310) by 15-lipoxygenase (15-LO) and is a precursor to 17(S)-resolvins.{13989,46682} 17(S)-HDHA inhibits platelet 12-LO (IC50 = 0.4 ?M).{46682} It inhibits TNF-a-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM).{13989} 17(S)-HDHA (100 nM) inhibits NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome formation induced by homocysteine in podocytes.{46683}
Specifications
Size
250 ug
CAS number
92693-03-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C