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(+-)-EX-527
10009798-5
5 mg
€40
Product description
EX-527 is an inhibitor of sirtuin 1 (SIRT1; IC50 = 0.098 µM).{48663} It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7 cells.{48664}
Specifications
CAS number
49843-98-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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