5(S),6(R)-11-trans DiHETE

5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor.{14924} 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue.{14924} The isomerase activity responsible for the conversion of leukotriene B4 (LTB4) to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation.{14925} 5(S),6(R)-11-trans DiHETE is not a substrate for soybean lipoxygenase.{14924} The biological activity of 5(S),6(R)-11-trans DiHETE has not been reported.