2,3-dinor Thromboxane B2-d9

2,3-dinor Thromboxane B2-d9 (2,3-dinor TXB2-d9) contains 9 deuterium atoms at the 15, 15, 16, 16, 17, 17, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of 2,3-dinor TXB2 (Item No. 19050) by GC- or LC-mass spectrometry. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} 2,3-dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker for in vivo TXA2 synthesis.{1410,629,717} In healthy male volunteers, the median excretion of 2,3-dinor TXB2 is 10.3 ng/hour (138 pg/mg creatine).{629}