Product description
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 ?M).{16482} Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM).{16480,16483} 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion.{16479} In addition, 6-AN causes glial neurodegeneration.{16481}
Specifications
CAS number
329-89-5
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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6-Aminonicotinamide

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