11B-Prostaglandin F2a-d4 (11B-PGF2a-d4) is intended for use as an internal standard for the quantification of 11B-PGF2a (Item No. 16520) by GC- or LC-MS. 11B-PGF2a is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11B-PGF2a induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2a (FP) receptors, with an EC50 value of 0.045 uM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 uM.{1756} 11B-PGF2a (0.1 and 1 uM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 uM.{57059}
Specifications
Size
500 ug
CAS number
1240398-18-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C