Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of w-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).{16509} EPA ethyl ester is a stabilized ethyl ester form of this w-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (w-6) arachidonic acid by cyclooxygenase enzymes,{16250} suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid B-oxidation enzyme levels,{16514,16499} indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.{16497} Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-a expression.{16498}
500 mg
CAS number
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature