Eicosapentaenoic Acid ethyl ester

Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the w-3 fatty acid EPA (Item Nos. 90110 | 90110.1 | 21908). Dietary administration of EPA ethyl ester (41.4 g/100 g of total dietary fatty acids) increases the ex vivo activity of hepatic B-oxidation enzymes.{16514,16499} It also reduces total hepatic triglyceride levels and increases the w-3 fatty acid content of hepatic triglycerides and phospholipids, as well as increases the total levels of w-3 fatty acids in rats. EPA ethyl ester (1 g/kg) reverses increases in plasma cholesterol levels and reduces circulating triglyceride levels in rats fed a high-fat diet.{16497} Formulations containing eicosapentaenoic acid ethyl ester have been used as adjuncts in the treatment of hypertriglyceridemia.