Product description
Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.{14974,14973,14972} 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX).{19393} It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA.{14974,19393} It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse.{14974} It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.{19393,19394}
Specifications
CAS number
871826-47-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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10(S),17(S)-DiHDHA

10008128-100

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10(S),17(S)-DiHDHA

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