18-hydroxy-11-deoxy Corticosterone

18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland.{45039,45040} Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. 24257) as well as angiotensin II (Item No. 17150), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells.{45039,45041} 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. 22916) in human SK-MEL188 melanoma cells.{45042} 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. 15876) and can be converted to aldosterone (Item No. 15273) by the capsular portion of rat adrenal glands.{45041,45042} Continuous infusion of 18-OH-DOC (200 ?g/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats.{45040} Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.{45043}