Product description
The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase y (iPLA2y). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2B except at high doses of 20-30 µM.{12978} (R)-BEL inhibits human recombinant iPLA2y with an IC50 of approximately 0.6 µM.
Specifications
CAS number
478288-90-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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(R)-Bromoenol lactone

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