Quercetin (hydrate)

Quercetin is an abundant flavonoid that has been isolated from a variety of fruits and vegetables and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{36990,36991,36992} Quercetin (5-100 mg/kg) reduces autophagy, decreases the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy.{36991} It reduces tumor growth, induces apoptosis, and halts the cell cycle at the G1 phase in an HL60 mouse xenograft model when administered at a dose of 120 mg/kg every four days.{36990} Quercetin (30 µM) also inhibits histamine release from antigen-stimulated RBL-2H3 cells and decreases the expression of TNF-a, IL-1B, IL-6, and IL-8 induced by PMACI in HMC-1 cells.{36992}